Generic Seromycin is used for treating tuberculosis in the lungs and other places in the body (including the kidneys) when treatment with other medicines has not been effective. This medicine should be used in combination with other medicines.
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CYCLOSERINE is an antibiotic. Cycloserine kills or interferes with the growth of bacteria that cause tuberculosis. It is usually reserved for patients with tuberculosis who have been unsuccessfully treated with other medicines.
Broad-spectrum antibiotic. Bacteriostatic or bactericidal, depending on the concentration in the inflammation and the sensitivity of microorganisms.
Penalized cell wall synthesis by acting as a competitive antagonist of D-alanine. Inhibits the activity of enzymes responsible for cell wall synthesis. Active against Gram-negative microorganisms in a concentration of 10-100 mg / L - Rickettsia spp., Treponema spp. MIC against Mycobacterium tuberculosis is a 3-25 mg / l liquid and 10-20 mg / l and more - on solid medium. Drug resistance occurs slowly (after 6 months of treatment develops in 20-80% of cases).
Absorption after oral administration - 70-90%. Practically does not bind to plasma proteins.
TCmax- 3-4 hours; in proportion to the dose of 0.25, 0.5 and 1 g Smaxsostavlyaet 6, 24 and 30 micrograms / liter respectively. After receiving 250 mg every 12 hours Smax- 25-30 ug / ml. It penetrates the body tissue and fluids, including cerebrospinal fluid, breast milk, bile, phlegm, lymph tissue, lung, synovial fluid and ascites, pleural effusion, passes through a placenta. In the abdominal and pleural cavities contained 50-100% of the drug concentration in the blood serum. Metabolized to 35% of reference dose. T1 / 2, with normal renal function -10 hours. The deduced by glomerular filtration unedited: 50% after 12 hours, 65-70% within 24-72 hours, a small amount - from the stool.
In chronic renal failure in 2-3 days might occur phenomena cumulation.
Inside, immediately before ingestion (with stimulation of the GI mucosa - after a meal), adults - 0.25 g every 12 h during the first 12 hours, and then, if necessary, taking into account the tolerance dose carefully increased to 250 mg every 6-8 hours under control drug concentration in the blood serum.
The maximum daily dose - 1 in patients over 60 years and weighing less than 50 kg - 0.25 g 2 times / day. The daily dose for children - 0.01-0.02 g / kg (not more than 0.75 g / day).
Increases the rate of excretion by the kidneys pyridoxine (can cause anemia and peripheral neuritis, requires an increase in the dose of pyridoxine). Ethanol increases the risk of seizures, especially in patients suffering from chronic alcoholism.
Ethionamide increases the risk of side effects from the central nervous system, especially seizures.
Isoniazid increases the incidence of dizziness, drowsiness.
Store in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life 2 years.
Do not use beyond the expiration date printed on the package.
Before therapy cycloserine must distinguish cultures of microorganisms and to determine the sensitivity of the strains to the drug. In the case of TB infection is necessary to determine the sensitivity of the strain to other anti-TB drugs buy seromycin.
Cycloserine treatment should be abolished or should reduce the dose if the patient develops allergic dermatitis or symptoms of central nervous system, such as: headache, dizziness, drowsiness, confusion, tremor, peripheral paresis, dysarthria, seizures and psychosis. Due to the low therapeutic index of cycloserine danger of seizures is increased in patients with chronic alcoholism buy seromycin.
Poisoning is usually observed at concentrations of drug in the blood is above 30 mg / l, which may result from overdose or impaired renal clearance. When receiving the drug should be monitored haematological parameters, renal function (creatinine concentration and blood urea nitrogen), the concentration of drug in the blood and liver function buy seromycin.
For patients with reduced renal function receiving a daily dose of 500 mg, and in which presumably show signs and symptoms of an overdose, drug levels must be monitored at least once a week. The dose must be adjusted so as to maintain drug levels below 30 mg / l buy seromycin.
For prevention of symptoms of central nervous system, in particular, convulsions or tremors excitation states, usage anticonvulsant or sedative. Patients receiving more than 500 mg of cycloserine per day, must be under the direct supervision of a physician because of the possible development of similar symptoms. Prevent or reduce the toxic effect of cycloserine can assigning during treatment glutamic acid, 500 mg 3-4 times / day (before meal) and daily / m introduction of the sodium salt of ATP (1 mL of 1% solution), and pyridoxine dose 200-300 mg / day buy seromycin online.
For the prevention of adverse effects of neurotoxic prescribed psychotropic medication benzodiazepine diazepam (5 mg) or Phenazepamum (1 mg) overnight and piracetam 800 mg 2 times / day. In some cases, the use of cycloserine can cause the development of vitamin B12 deficiency and / or folate, megaloblastic and sideroblastic anemia. In case of anemia during treatment is necessary to conduct an appropriate examination and treatment of the patient buy seromycin online.
Should limit the mental stress of patients and prevent possible overheating of the factors (exposure to the sun bareheaded, hot shower).
With the rapid development of resistance in monotherapy cycloserine recommended its combination with other anti-TB drugs buy seromycin online.
Effect of receiving cycloserine on ability to drive and use machinery has been established.
organic diseases of the central nervous system;
seizures (including in history);
mental disorders (anxiety, psychosis, depression, including in history);
Chronic heart nedostatochnst;
chronic renal insufficiency (creatinine clearance less than 50 ml / min);
Be wary of a child.